III.2.B.j. Angiotensinogen
This is a member of the renin-angiotensin-aldosterone system (RAAS).
The adipose tissue secretes both angiotensinogen and ACE.
Its main effects: It inhibits insulin sensitivity.
It increases BP.
It enhances the glycogen metabolism and Glu synthesis in the liver.
It inhibits insulin-induced Glu uptake in tissues.
It increases the synthesis of fatty acids and prostaglandin (PG).
It indirectly increases the levels of leptin, PAI-1, NO and prostacyclin (PGI2) through A-II.
It is stimulated by obesity and the consumption of fatty food.
It is inhibited by a loss in weight.
The development of CVD and the MetS is reduced by the inhibition of RAAS.
The BP falls on average by 7 mmHg in response to a body weight loss of 5%. At the same time the levels of various enzymes also fall, e.g. that of angiotensinogen by 30%, that of renin by 43%, that of ACE by 12% and that of aldosterone by 31%.