III.2.B.c. Resistin

It is synthesized in the adipose tissue, hypothalamus, adrenal glands, spleen, pancreas, skeletal muscle and GIT.

Resistin is not detected in lean individuals, but its level is high in obese patients. Women have a higher resistin level. Its level decreases during fasting and increases after eating.  

Effects: It inhibits insulin and Glu sensitivity;

insulin-induced Glu uptake and

the release of dopamine (DA) and N in the brain.

It increases TNF-α and IL-6 production in the liver and

NPY synthesis.

Its expression is inhibited by the diuretic thiazolidinediones (TZD).

Although its effects are not completely clear, it is suggested that resistin has roles in the pathogenesis of arthritis, inflammatory bowel disease (IBD) and other inflammatory disorders and CVD.