References

Abu-Fanne, R., A. Brzezinski, M. Golomb, E. Grad, A. J. Foldes, Y. Shufaro, D. Varon, A. Brill, C. Lotan and H. D. Danenberg (2008). "Effects of estradiol and raloxifene on arterial thrombosis in ovariectomized mice." Menopause 15(1): 98-104.

Ahmed, I. and B. J. Goldstein (2006). "Cardiovascular risk in the spectrum of type 2 diabetes mellitus." Mt Sinai J Med 73(5): 759-768.

Arenas, I. A., S. J. Armstrong, Y. Xu and S. T. Davidge (2005). "Chronic tumor necrosis factor-alpha inhibition enhances NO modulation of vascular function in estrogen-deficient rats." Hypertension 46(1): 76-81.

Bailey, C. J. and H. Ahmed-Sorour (1980). "Role of ovarian hormones in the long-term control of glucose homeostasis. Effects of insulin secretion." Diabetologia 19(5): 475-481.

Barrett-Connor, E., D. Grady, A. Sashegyi, P. W. Anderson, D. A. Cox, K. Hoszowski, P. Rautaharju and K. D. Harper (2002). "Raloxifene and cardiovascular events in osteoporotic postmenopausal women: four-year results from the MORE (Multiple Outcomes of Raloxifene Evaluation) randomized trial." Jama 287(7): 847-857.

Barrett-Connor, E., D. Grady, A. Sashegyi, P. W. Anderson, D. A. Cox, K. Hoszowski, P. Rautaharju, K. D. Harper and M. Investigators (2002). "Raloxifene and cardiovascular events in osteoporotic postmenopausal women: four-year results from the MORE (Multiple Outcomes of Raloxifene Evaluation) randomized trial." JAMA 287(7): 847-857.

Barrett-Connor, E., L. Mosca, P. Collins, M. J. Geiger, D. Grady, M. Kornitzer, M. A. McNabb and N. K. Wenger (2006). "Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women." N Engl J Med 355(2): 125-137.

Barros, R. P. and J. A. Gustafsson (2011). "Estrogen receptors and the metabolic network." Cell Metab 14(3): 289-299.

Beral, V., E. Banks and G. Reeves (2002). "Evidence from randomised trials on the long-term effects of hormone replacement therapy." Lancet 360(9337): 942-944.

Bolognese, M. A. (2010). "SERMs and SERMs with estrogen for postmenopausal osteoporosis." Rev Endocr Metab Disord 11(4): 253-259.

Bonora, E. (2006). "The metabolic syndrome and cardiovascular disease." Ann Med 38(1): 64-80.

Borgo, M. V., A. B. Lopes, S. A. Gouvea, W. G. Romero, M. R. Moyses, N. S. Bissoli and G. R. Abreu (2011). "Effect of tamoxifen on the coronary vascular reactivity of spontaneously hypertensive female rats." Braz J Med Biol Res 44(8): 786-792.

Brown, R. A., M. J. Anthony, P. Petrovski and J. Ren (2001). "The influence of gender, diabetes, and acetaldehyde on the intrinsic contractile properties of isolated rat myocardium." Cardiovasc Toxicol 1(1): 35-42.

Brown, W. J., D. McLaughlin, J. Leung, K. A. McCaul, L. Flicker, O. P. Almeida, G. J. Hankey, D. Lopez and A. J. Dobson (2012). "Physical activity and all-cause mortality in older women and men." Br J Sports Med 46(9): 664-668.

Bruce, C. R., A. B. Thrush, V. A. Mertz, V. Bezaire, A. Chabowski, G. J. Heigenhauser and D. J. Dyck (2006). "Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content." Am J Physiol Endocrinol Metab 291(1): E99-E107.

Cameron, I., M. A. Alam, J. Wang and L. Brown (2012). "Endurance exercise in a rat model of metabolic syndrome." Can J Physiol Pharmacol 90(11): 1490-1497.

Camporez, J. P., F. R. Jornayvaz, H. Y. Lee, S. Kanda, B. A. Guigni, M. Kahn, V. T. Samuel, C. R. Carvalho, K. F. Petersen, M. J. Jurczak and G. I. Shulman (2013). "Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance." Endocrinology 154(3): 1021-1028.

Cauley, J. A., F. L. Lucas, L. H. Kuller, M. T. Vogt, W. S. Browner and S. R. Cummings (1996). "Bone mineral density and risk of breast cancer in older women: the study of osteoporotic fractures. Study of Osteoporotic Fractures Research Group." JAMA 276(17): 1404-1408.

Celik, A., F. Koc, H. Kadi, K. Ceyhan and U. Erkorkmaz (2012). "Inflammation is related to unbalanced cardiac autonomic functions in hypertension: an observational study." Anadolu Kardiyol Derg 12(3): 233-240.

Cetinkaya Demir, B., Y. Uyar, K. Ozbilgin and C. Kose (2013). "Effect of raloxifene and atorvastatin in atherosclerotic process in ovariectomized rats." J Obstet Gynaecol Res 39(1): 229-236.

Chan, Y. C., F. P. Leung, X. Yao, C. W. Lau, P. M. Vanhoutte and Y. Huang (2007). "Raloxifene modulates pulmonary vascular reactivity in spontaneously hypertensive rats." J Cardiovasc Pharmacol 49(6): 355-361.

Chen, T. M., J. Li, L. Liu, L. Fan, X. Y. Li, Y. T. Wang, N. G. Abraham and J. Cao (2013). "Effects of heme oxygenase-1 upregulation on blood pressure and cardiac function in an animal model of hypertensive myocardial infarction." Int J Mol Sci 14(2): 2684-2706.

Chen, Y. H., S. F. Yet and M. A. Perrella (2003). "Role of heme oxygenase-1 in the regulation of blood pressure and cardiac function." Exp Biol Med (Maywood) 228(5): 447-453.

Choi, A. M. (2001). "Heme oxygenase-1 protects the heart." Circ Res 89(2): 105-107.

Christodoulakos, G. E., I. V. Lambrinoudaki and D. C. Botsis (2006). "The cardiovascular effects of selective estrogen receptor modulators." Ann N Y Acad Sci 1092: 374-384.

Claudio, E. R., P. W. Endlich, R. L. Santos, M. R. Moyses, N. S. Bissoli, S. A. Gouvea, J. F. Silva, V. S. Lemos and G. R. Abreu (2013). "Effects of chronic swimming training and oestrogen therapy on coronary vascular reactivity and expression of antioxidant enzymes in ovariectomized rats." PLoS One 8(6): e64806.

Colacurci, N., D. Manzella, F. Fornaro, M. Carbonella and G. Paolisso (2003). "Endothelial function and menopause: effects of raloxifene administration." J Clin Endocrinol Metab 88(5): 2135-2140.

Cortese-Krott, M. M., L. Kulakov, C. Oplander, V. Kolb-Bachofen, K. D. Kroncke and C. V. Suschek (2014). "Zinc regulates iNOS-derived nitric oxide formation in endothelial cells." Redox Biol 2: 945-954.

Cummings, S. R., B. Ettinger, P. D. Delmas, P. Kenemans, V. Stathopoulos, P. Verweij, M. Mol-Arts, L. Kloosterboer, L. Mosca, C. Christiansen, J. Bilezikian, E. M. Kerzberg, S. Johnson, J. Zanchetta, D. E. Grobbee, W. Seifert, R. Eastell and L. T. Investigators (2008). "The effects of tibolone in older postmenopausal women." N Engl J Med 359(7): 697-708.

Dandona, P., A. Aljada, A. Chaudhuri, P. Mohanty and R. Garg (2005). "Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation." Circulation 111(11): 1448-1454.

Dantas, A. P., R. C. Tostes, Z. B. Fortes, S. G. Costa, D. Nigro and M. H. Carvalho (2002). "In vivo evidence for antioxidant potential of estrogen in microvessels of female spontaneously hypertensive rats." Hypertension 39(2 Pt 2): 405-411.

de Castro, U. G., R. A. dos Santos, M. E. Silva, W. G. de Lima, M. J. Campagnole-Santos and A. C. Alzamora (2013). "Age-dependent effect of high-fructose and high-fat diets on lipid metabolism and lipid accumulation in liver and kidney of rats." Lipids Health Dis 12: 136.

Drazner, M. H. (2011). "The progression of hypertensive heart disease." Circulation 123(3): 327-334.

Dubey, R. K. and E. K. Jackson (2001). "Estrogen-induced cardiorenal protection: potential cellular, biochemical, and molecular mechanisms." Am J Physiol Renal Physiol 280(3): F365-388.

Dubey, R. K., Y. Y. Tyurina, V. A. Tyurin, D. G. Gillespie, R. A. Branch, E. K. Jackson and V. E. Kagan (1999). "Estrogen and tamoxifen metabolites protect smooth muscle cell membrane phospholipids against peroxidation and inhibit cell growth." Circ Res 84(2): 229-239.

Egan, K. M., J. A. Lawson, S. Fries, B. Koller, D. J. Rader, E. M. Smyth and G. A. Fitzgerald (2004). "COX-2-derived prostacyclin confers atheroprotection on female mice." Science 306(5703): 1954-1957.

El-Haschimi, K., D. D. Pierroz, S. M. Hileman, C. Bjorbaek and J. S. Flier (2000). "Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity." J Clin Invest 105(12): 1827-1832.

Endlich, P. W., E. R. Claudio, W. L. da Silva Goncalves, S. A. Gouvea, M. R. Moyses and G. R. de Abreu (2013). "Swimming training prevents fat deposition and decreases angiotensin II-induced coronary vasoconstriction in ovariectomized rats." Peptides 47: 29-35.

Ettinger, B., S. M. Wang, R. S. Leslie, B. V. Patel, M. J. Boulware, M. E. Mann and M. McBride (2012). "Evolution of postmenopausal hormone therapy between 2002 and 2009." Menopause 19(6): 610-615.

Fernandes, T., J. S. Nakamuta, F. C. Magalhaes, F. R. Roque, C. Lavini-Ramos, I. T. Schettert, V. Coelho, J. E. Krieger and E. M. Oliveira (2012). "Exercise training restores the endothelial progenitor cells number and function in hypertension: implications for angiogenesis." J Hypertens 30(11): 2133-2143.

Flores, M. B., M. F. Fernandes, E. R. Ropelle, M. C. Faria, M. Ueno, L. A. Velloso, M. J. Saad and J. B. Carvalheira (2006). "Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar rats." Diabetes 55(9): 2554-2561.

Friedman, J. M. (2009). "Leptin at 14 y of age: an ongoing story." Am J Clin Nutr 89(3): 973S-979S.

Friedman, J. M. and J. L. Halaas (1998). "Leptin and the regulation of body weight in mammals." Nature 395(6704): 763-770.

Fukai, T., M. R. Siegfried, M. Ushio-Fukai, Y. Cheng, G. Kojda and D. G. Harrison (2000). "Regulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training." J Clin Invest 105(11): 1631-1639.

Gami, A. S., B. J. Witt, D. E. Howard, P. J. Erwin, L. A. Gami, V. K. Somers and V. M. Montori (2007). "Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies." J Am Coll Cardiol 49(4): 403-414.

Gaynor, J. S., E. Monnet, C. Selzman, D. Parker, L. Kaufman, H. U. Bryant, C. Mallinckrodt, R. Wrigley, T. Whitehill and A. S. Turner (2000). "The effect of raloxifene on coronary arteries in aged ovariectomized ewes." J Vet Pharmacol Ther 23(3): 175-179.

Gielen, S., G. Schuler and V. Adams (2010). "Cardiovascular effects of exercise training: molecular mechanisms." Circulation 122(12): 1221-1238.

Grover-Paez, F., A. B. Zavalza-Gomez and R. Anaya-Prado (2013). "Raloxifene modifies the insulin sensitivity and lipid profile of postmenopausal insulin resistant women." Gynecol Endocrinol 29(7): 674-677.

Hamilton, K. L., L. Lin, Y. Wang and A. A. Knowlton (2008). "Effect of ovariectomy on cardiac gene expression: inflammation and changes in SOCS gene expression." Physiol Genomics 32(2): 254-263.

Hamilton, K. L., J. C. Quindry, J. P. French, J. Staib, J. Hughes, J. L. Mehta and S. K. Powers (2004). "MnSOD antisense treatment and exercise-induced protection against arrhythmias." Free Radic Biol Med 37(9): 1360-1368.

Han, Y., Y. Joe, E. Seo, S. R. Lee, M. K. Park, H. J. Lee and D. K. Kim (2010). "The hyperleptinemia and ObRb expression in hyperphagic obese rats." Biochem Biophys Res Commun 394(1): 70-74.

Hanley, A. J., K. Williams, A. Festa, L. E. Wagenknecht, R. B. D'Agostino, Jr. and S. M. Haffner (2005). "Liver markers and development of the metabolic syndrome: the insulin resistance atherosclerosis study." Diabetes 54(11): 3140-3147.

Hertrampf, T., M. J. Gruca, J. Seibel, U. Laudenbach, K. H. Fritzemeier and P. Diel (2007). "The bone-protective effect of the phytoestrogen genistein is mediated via ER alpha-dependent mechanisms and strongly enhanced by physical activity." Bone 40(6): 1529-1535.

Innes, K. E., T. K. Selfe and A. G. Taylor (2008). "Menopause, the metabolic syndrome, and mind-body therapies." Menopause 15(5): 1005-1013.

Iwakura, A., S. Shastry, C. Luedemann, H. Hamada, A. Kawamoto, R. Kishore, Y. Zhu, G. Qin, M. Silver, T. Thorne, L. Eaton, H. Masuda, T. Asahara and D. W. Losordo (2006). "Estradiol enhances recovery after myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced neovascularization via endothelial nitric oxide synthase-mediated activation of matrix metalloproteinase-9." Circulation 113(12): 1605-1614.

Jochems, C., U. Islander, A. Kallkopf, M. Lagerquist, C. Ohlsson and H. Carlsten (2007). "Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis." Arthritis Rheum 56(10): 3261-3270.

Jochems, C., M. Lagerquist, C. Hakansson, C. Ohlsson and H. Carlsten (2008). "Long-term anti-arthritic and anti-osteoporotic effects of raloxifene in established experimental postmenopausal polyarthritis." Clin Exp Immunol 152(3): 593-597.

Jones, M. E., A. W. Thorburn, K. L. Britt, K. N. Hewitt, N. G. Wreford, J. Proietto, O. K. Oz, B. J. Leury, K. M. Robertson, S. Yao and E. R. Simpson (2000). "Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity." Proc Natl Acad Sci U S A 97(23): 12735-12740.

Kang, S., K. B. Kim and K. O. Shin (2013). "Exercise training improves leptin sensitivity in peripheral tissue of obese rats." Biochem Biophys Res Commun 435(3): 454-459.

Keller, C., P. Keller, M. Giralt, J. Hidalgo and B. K. Pedersen (2004). "Exercise normalises overexpression of TNF-alpha in knockout mice." Biochem Biophys Res Commun 321(1): 179-182.

Kireev, R. A., A. C. Tresguerres, C. Garcia, C. Borras, C. Ariznavarreta, E. Vara, J. Vina and J. A. Tresguerres (2010). "Hormonal regulation of pro-inflammatory and lipid peroxidation processes in liver of old ovariectomized female rats." Biogerontology 11(2): 229-243.

Kokkinos, P., A. Pittaras, P. Narayan, C. Faselis, S. Singh and A. Manolis (2007). "Exercise capacity and blood pressure associations with left ventricular mass in prehypertensive individuals." Hypertension 49(1): 55-61.

Kozma, F., R. A. Johnson, F. Zhang, C. Yu, X. Tong and A. Nasjletti (1999). "Contribution of endogenous carbon monoxide to regulation of diameter in resistance vessels." Am J Physiol 276(4 Pt 2): R1087-1094.

Lakatta, E. G. and D. Levy (2003). "Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part II: the aging heart in health: links to heart disease." Circulation 107(2): 346-354.

Lakka, T. A., J. M. Venalainen, R. Rauramaa, R. Salonen, J. Tuomilehto and J. T. Salonen (1994). "Relation of leisure-time physical activity and cardiorespiratory fitness to the risk of acute myocardial infarction." N Engl J Med 330(22): 1549-1554.

Laufs, U., N. Werner, A. Link, M. Endres, S. Wassmann, K. Jurgens, E. Miche, M. Bohm and G. Nickenig (2004). "Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis." Circulation 109(2): 220-226.

Lee, S., Y. Park, M. Y. Zuidema, M. Hannink and C. Zhang (2011). "Effects of interventions on oxidative stress and inflammation of cardiovascular diseases." World J Cardiol 3(1): 18-24.

Lee, Y. M., P. Y. Cheng, S. F. Hong, S. Y. Chen, K. K. Lam, J. R. Sheu and M. H. Yen (2005). "Oxidative stress induces vascular heme oxygenase-1 expression in ovariectomized rats." Free Radic Biol Med 39(1): 108-117.

Leeuwenburgh, C. and J. W. Heinecke (2001). "Oxidative stress and antioxidants in exercise." Curr Med Chem 8(7): 829-838.

Leite, R. D., C. Durigan Rde, A. D. de Souza Lino, M. V. de Souza Campos, M. Souza, H. S. Selistre-de-Araujo, E. Bouskela and L. G. Kraemer-Aguiar (2013). "Resistance training may concomitantly benefit body composition, blood pressure and muscle MMP-2 activity on the left ventricle of high-fat fed diet rats." Metabolism 62(10): 1477-1484.

Lennon, S. L., J. C. Quindry, K. L. Hamilton, J. P. French, J. Hughes, J. L. Mehta and S. K. Powers (2004). "Elevated MnSOD is not required for exercise-induced cardioprotection against myocardial stunning." Am J Physiol Heart Circ Physiol 287(2): H975-980.

Lessard, S. J., D. A. Rivas, Z. P. Chen, A. Bonen, M. A. Febbraio, D. W. Reeder, B. E. Kemp, B. B. Yaspelkis, 3rd and J. A. Hawley (2007). "Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance." Diabetes 56(7): 1856-1864.

Leung, F. P., S. Y. Tsang, C. M. Wong, L. M. Yung, Y. C. Chan, H. S. Leung, X. Yao and Y. Huang (2007). "Raloxifene, tamoxifen and vascular tone." Clin Exp Pharmacol Physiol 34(8): 809-813.

Leung, F. P., L. M. Yung, H. S. Leung, C. L. Au, X. Yao, P. M. Vanhoutte, I. Laher and Y. Huang (2007). "Therapeutic concentrations of raloxifene augment nitric oxide-dependent coronary artery dilatation in vitro." Br J Pharmacol 152(2): 223-229.

Lieber, C. S., M. A. Leo, K. M. Mak, Y. Xu, Q. Cao, C. Ren, A. Ponomarenko and L. M. DeCarli (2004). "Model of nonalcoholic steatohepatitis." Am J Clin Nutr 79(3): 502-509.

Liu, M. L., X. Xu, W. Q. Rang, Y. J. Li and H. P. Song (2004). "Influence of ovariectomy and 17beta-estradiol treatment on insulin sensitivity, lipid metabolism and post-ischemic cardiac function." Int J Cardiol 97(3): 485-493.

Lobo, R. A. (2008). "Metabolic syndrome after menopause and the role of hormones." Maturitas 60(1): 10-18.

Lovejoy, J. C., C. M. Champagne, L. de Jonge, H. Xie and S. R. Smith (2008). "Increased visceral fat and decreased energy expenditure during the menopausal transition." Int J Obes (Lond) 32(6): 949-958.

Lu, R., J. Peng, L. Xiao, H. W. Deng and Y. J. Li (2002). "Heme oxygenase-1 pathway is involved in delayed protection induced by heat stress against cardiac ischemia-reperfusion injury." Int J Cardiol 82(2): 133-140.

Mainardi, M., G. Scabia, T. Vottari, F. Santini, A. Pinchera, L. Maffei, T. Pizzorusso and M. Maffei (2010). "A sensitive period for environmental regulation of eating behavior and leptin sensitivity." Proc Natl Acad Sci U S A 107(38): 16673-16678.

Marcantoni, E., L. Di Francesco, M. Dovizio, A. Bruno and P. Patrignani (2012). "Novel insights into the vasoprotective role of heme oxygenase-1." Int J Hypertens 2012: 127910.

Mauvais-Jarvis, F. (2011). "Estrogen and androgen receptors: regulators of fuel homeostasis and emerging targets for diabetes and obesity." Trends Endocrinol Metab 22(1): 24-33.

Mendelsohn, M. E. and R. H. Karas (1999). "The protective effects of estrogen on the cardiovascular system." N Engl J Med 340(23): 1801-1811.

Mestek, M. L., E. Plaisance and P. Grandjean (2008). "The relationship between pedometer-determined and self-reported physical activity and body composition variables in college-aged men and women." J Am Coll Health 57(1): 39-44.

Meziri, F., D. Binda, S. Touati, M. Pellegrin, A. Berthelot, R. M. Touyz and P. Laurant (2011). "Exercise aggravates cardiovascular risks and mortality in rats with disrupted nitric oxide pathway and treated with recombinant human erythropoietin." Eur J Appl Physiol 111(8): 1929-1938.

Mizushima, Y., P. Wang, D. Jarrar, W. G. Cioffi, K. I. Bland and I. H. Chaudry (2000). "Estradiol administration after trauma-hemorrhage improves cardiovascular and hepatocellular functions in male animals." Ann Surg 232(5): 673-679.

North, B. J. and D. A. Sinclair (2012). "The intersection between aging and cardiovascular disease." Circ Res 110(8): 1097-1108.

Oghlakian, G. and M. Klapholz (2009). "Vasopressin and Vasopressin Receptor Antagonists in Heart Failure." Cardiology in Review 17(1): 10-15.

Ogita, H., K. Node, H. Asanuma, S. Sanada, Y. Liao, S. Takashima, M. Asakura, H. Mori, Y. Shinozaki, M. Hori and M. Kitakaze (2002). "Amelioration of ischemia- and reperfusion-induced myocardial injury by the selective estrogen receptor modulator, raloxifene, in the canine heart." J Am Coll Cardiol 40(5): 998-1005.

Okabe, T. A., K. Shimada, M. Hattori, T. Murayama, M. Yokode, T. Kita and C. Kishimoto (2007). "Swimming reduces the severity of atherosclerosis in apolipoprotein E deficient mice by antioxidant effects." Cardiovasc Res 74(3): 537-545.

Osborne, C. K. (1998). "Tamoxifen in the treatment of breast cancer." N Engl J Med 339(22): 1609-1618.

Paulino, E. C., J. C. Ferreira, L. R. Bechara, J. M. Tsutsui, W. Mathias, Jr., F. B. Lima, D. E. Casarini, A. C. Cicogna, P. C. Brum and C. E. Negrao (2010). "Exercise training and caloric restriction prevent reduction in cardiac Ca2+-handling protein profile in obese rats." Hypertension 56(4): 629-635.

Pavo, I., F. Laszlo, E. Morschl, J. Nemcsik, A. Berko, D. A. Cox and F. A. Laszlo (2000). "Raloxifene, an oestrogen-receptor modulator, prevents decreased constitutive nitric oxide and vasoconstriction in ovariectomized rats." Eur J Pharmacol 410(1): 101-104.

Pinna, C., C. Bolego, P. Sanvito, V. Pelosi, R. Baetta, A. Corsini, R. M. Gaion and A. Cignarella (2006). "Raloxifene elicits combined rapid vasorelaxation and long-term anti-inflammatory actions in rat aorta." J Pharmacol Exp Ther 319(3): 1444-1451.

Pinto, A., D. Di Raimondo, A. Tuttolomondo, C. Butta, G. Milio and G. Licata (2012). "Effects of physical exercise on inflammatory markers of atherosclerosis." Curr Pharm Des 18(28): 4326-4349.

Posa, A., K. Kupai, R. Menesi, Z. Szalai, R. Szabo, Z. Pinter, G. Palfi, M. Gyongyosi, A. Berko, I. Pavo and C. Varga (2013). "Sexual dimorphism of cardiovascular ischemia susceptibility is mediated by heme oxygenase." Oxid Med Cell Longev 2013: 521563.

Rahimian, R., G. P. Dube, W. Toma, N. Dos Santos, B. M. McManus and C. van Breemen (2002). "Raloxifene enhances nitric oxide release in rat aorta via increasing endothelial nitric oxide mRNA expression." Eur J Pharmacol 434(3): 141-149.

Ren, X. P., J. Wu, X. Wang, M. A. Sartor, J. Qian, K. Jones, P. Nicolaou, T. J. Pritchard and G. C. Fan (2009). "MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20." Circulation 119(17): 2357-2366.

Riant, E., A. Waget, H. Cogo, J. F. Arnal, R. Burcelin and P. Gourdy (2009). "Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice." Endocrinology 150(5): 2109-2117.

Richard, D., L. Rochon and Y. Deshaies (1987). "Effects of exercise training on energy balance of ovariectomized rats." Am J Physiol 253(5 Pt 2): R740-745.

Rogers, N. H., J. W. Perfield, 2nd, K. J. Strissel, M. S. Obin and A. S. Greenberg (2009). "Reduced energy expenditure and increased inflammation are early events in the development of ovariectomy-induced obesity." Endocrinology 150(5): 2161-2168.

Roque, F. R., A. M. Briones, A. B. Garcia-Redondo, M. Galan, S. Martinez-Revelles, M. S. Avendano, V. Cachofeiro, T. Fernandes, D. V. Vassallo, E. M. Oliveira and M. Salaices (2013). "Aerobic exercise reduces oxidative stress and improves vascular changes of small mesenteric and coronary arteries in hypertension." Br J Pharmacol 168(3): 686-703.

Ross, J. L. and S. E. Howlett (2012). "Age and ovariectomy abolish beneficial effects of female sex on rat ventricular myocytes exposed to simulated ischemia and reperfusion." PLoS One 7(6): e38425.

Sabaawy, H. E., F. Zhang, X. Nguyen, A. ElHosseiny, A. Nasjletti, M. Schwartzman, P. Dennery, A. Kappas and N. G. Abraham (2001). "Human heme oxygenase-1 gene transfer lowers blood pressure and promotes growth in spontaneously hypertensive rats." Hypertension 38(2): 210-215.

Saengsirisuwan, V., S. Pongseeda, M. Prasannarong, K. Vichaiwong and C. Toskulkao (2009). "Modulation of insulin resistance in ovariectomized rats by endurance exercise training and estrogen replacement." Metabolism 58(1): 38-47.

Sato, M., M. K. Rippy and H. U. Bryant (1996). "Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats." FASEB J 10(8): 905-912.

Schindhelm, R. K., L. P. van der Zwan, T. Teerlink and P. G. Scheffer (2009). "Myeloperoxidase: a useful biomarker for cardiovascular disease risk stratification?" Clin Chem 55(8): 1462-1470.

Shimokawa, I. and Y. Higami (2001). "Leptin and anti-aging action of caloric restriction." J Nutr Health Aging 5(1): 43-48.

Shimokawa, I. and Y. Higami (2001). "Leptin signaling and aging: insight from caloric restriction." Mech Ageing Dev 122(14): 1511-1519.

Simpson, E., M. Jones, M. Misso, K. Hewitt, R. Hill, L. Maffei, C. Carani and W. C. Boon (2005). "Estrogen, a fundamental player in energy homeostasis." J Steroid Biochem Mol Biol 95(1-5): 3-8.

Siu, P. M., D. A. Donley, R. W. Bryner and S. E. Alway (2003). "Citrate synthase expression and enzyme activity after endurance training in cardiac and skeletal muscles." J Appl Physiol (1985) 94(2): 555-560.

Soci, U. P., T. Fernandes, N. Y. Hashimoto, G. F. Mota, M. A. Amadeu, K. T. Rosa, M. C. Irigoyen, M. I. Phillips and E. M. Oliveira (2011). "MicroRNAs 29 are involved in the improvement of ventricular compliance promoted by aerobic exercise training in rats." Physiol Genomics 43(11): 665-673.

Starnes, J. W., R. P. Taylor and Y. Park (2003). "Exercise improves postischemic function in aging hearts." Am J Physiol Heart Circ Physiol 285(1): H347-351.

Steinkellner, A. R., S. E. Denison, S. L. Eldridge, L. L. Lenzi, W. Chen and S. J. Bowlin (2012). "A decade of postmenopausal hormone therapy prescribing in the United States: long-term effects of the Women's Health Initiative." Menopause 19(6): 616-621.

Sullivan, T. R., Jr., R. H. Karas, M. Aronovitz, G. T. Faller, J. P. Ziar, J. J. Smith, T. F. O'Donnell, Jr. and M. E. Mendelsohn (1995). "Estrogen inhibits the response-to-injury in a mouse carotid artery model." J Clin Invest 96(5): 2482-2488.

Sun, M. W., M. F. Zhong, J. Gu, F. L. Qian, J. Z. Gu and H. Chen (2008). "Effects of different levels of exercise volume on endothelium-dependent vasodilation: roles of nitric oxide synthase and heme oxygenase." Hypertens Res 31(4): 805-816.

Szalai, Z., A. Szasz, I. Nagy, L. G. Puskas, K. Kupai, A. Kiraly, A. M. Berko, A. Posa, G. Strifler, Z. Barath, L. I. Nagy, R. Szabo, I. Pavo, Z. Murlasits, M. Gyongyosi and C. Varga (2014). "Anti-inflammatory effect of recreational exercise in TNBS-induced colitis in rats: role of NOS/HO/MPO system." Oxid Med Cell Longev 2014: 925981.

Szalay, L., T. Shimizu, M. G. Schwacha, M. A. Choudhry, L. W. Rue, 3rd, K. I. Bland and I. H. Chaudry (2005). "Mechanism of salutary effects of estradiol on organ function after trauma-hemorrhage: upregulation of heme oxygenase." Am J Physiol Heart Circ Physiol 289(1): H92-98.

Takahashi, K., A. Mori-Abe, K. Takata, T. Ohta, J. Kawagoe, S. Tsutsumi, M. Ohmichi and H. Kurachi (2007). "Raloxifene improves the ovariectomy-induced impairment in endothelium-dependent vasodilation." Menopause 14(4): 656-661.

Tanaka, L. Y., L. R. Bechara, A. M. dos Santos, C. P. Jordao, L. G. de Sousa, T. Bartholomeu, L. I. Ventura, F. R. Laurindo and P. R. Ramires (2015). "Exercise improves endothelial function: a local analysis of production of nitric oxide and reactive oxygen species." Nitric Oxide 45: 7-14.

Teixeira de Lemos, E., F. Reis, S. Baptista, R. Pinto, B. Sepodes, H. Vala, P. Rocha-Pereira, G. Correia da Silva, N. Teixeira, A. S. Silva, L. Carvalho, F. Teixeira and U. N. Das (2009). "Exercise training decreases proinflammatory profile in Zucker diabetic (type 2) fatty rats." Nutrition 25(3): 330-339.

Thum, T., P. Galuppo, C. Wolf, J. Fiedler, S. Kneitz, L. W. van Laake, P. A. Doevendans, C. L. Mummery, J. Borlak, A. Haverich, C. Gross, S. Engelhardt, G. Ertl and J. Bauersachs (2007). "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure." Circulation 116(3): 258-267.

Touati, S., F. Meziri, S. Devaux, A. Berthelot, R. M. Touyz and P. Laurant (2011). "Exercise reverses metabolic syndrome in high-fat diet-induced obese rats." Med Sci Sports Exerc 43(3): 398-407.

Tschugguel, W., F. Stonek, Z. Zhegu, W. Dietrich, C. Schneeberger, T. Stimpfl, T. Waldhoer, W. Vycudilik and J. C. Huber (2001). "Estrogen increases endothelial carbon monoxide, heme oxygenase 2, and carbon monoxide-derived cGMP by a receptor-mediated system." J Clin Endocrinol Metab 86(8): 3833-3839.

Vasa, M., S. Fichtlscherer, A. Aicher, K. Adler, C. Urbich, H. Martin, A. M. Zeiher and S. Dimmeler (2001). "Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease." Circ Res 89(1): E1-7.

Vatten, L. J., T. I. Nilsen and J. Holmen (2006). "Combined effect of blood pressure and physical activity on cardiovascular mortality." J Hypertens 24(10): 1939-1946.

Wang, G. K., J. Q. Zhu, J. T. Zhang, Q. Li, Y. Li, J. He, Y. W. Qin and Q. Jing (2010). "Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans." Eur Heart J 31(6): 659-666.

Wang, T., Z. Gou, F. Wang, M. Ma and S. D. Zhai (2014). "Comparison of GLP-1 analogues versus sitagliptin in the management of type 2 diabetes: systematic review and meta-analysis of head-to-head studies." PLoS One 9(8): e103798.

Wassmann, S., A. T. Baumer, K. Strehlow, M. van Eickels, C. Grohe, K. Ahlbory, R. Rosen, M. Bohm and G. Nickenig (2001). "Endothelial dysfunction and oxidative stress during estrogen deficiency in spontaneously hypertensive rats." Circulation 103(3): 435-441.

Weber, M., M. B. Baker, J. P. Moore and C. D. Searles (2010). "MiR-21 is induced in endothelial cells by shear stress and modulates apoptosis and eNOS activity." Biochem Biophys Res Commun 393(4): 643-648.

Weiderpass, E., H. O. Adami, J. A. Baron, C. Magnusson, A. Lindgren and I. Persson (1999). "Use of oral contraceptives and endometrial cancer risk (Sweden)." Cancer Causes Control 10(4): 277-284.

Wong, C. M., X. Yao, C. L. Au, S. Y. Tsang, K. P. Fung, I. Laher, P. M. Vanhoutte and Y. Huang (2006). "Raloxifene prevents endothelial dysfunction in aging ovariectomized female rats." Vascul Pharmacol 44(5): 290-298.

Wong, C. M., L. M. Yung, F. P. Leung, S. Y. Tsang, C. L. Au, Z. Y. Chen, X. Yao, C. H. Cheng, C. W. Lau, M. Gollasch and Y. Huang (2008). "Raloxifene protects endothelial cell function against oxidative stress." Br J Pharmacol 155(3): 326-334.

Xu, D., W. Niu, Y. Luo, B. Zhang, M. Liu, H. Dong, Y. Liu and Z. Li (2013). "Endogenous estrogen attenuates hypoxia-induced pulmonary hypertension by inhibiting pulmonary arterial vasoconstriction and pulmonary arterial smooth muscle cells proliferation." Int J Med Sci 10(6): 771-781.

Yang, A. L., C. J. Jen and H. I. Chen (2003). "Effects of high-cholesterol diet and parallel exercise training on the vascular function of rabbit aortas: a time course study." J Appl Physiol (1985) 95(3): 1194-1200.

Zanchi, N. E., L. R. Bechara, L. Y. Tanaka, V. Debbas, T. Bartholomeu and P. R. Ramires (2008). "Moderate exercise training decreases aortic superoxide production in myocardial infarcted rats." Eur J Appl Physiol 104(6): 1045-1052.

Zeng, C., F. Yang, H. He, K. Hu, X. Wang, Q. Hu and J. Li (2014). "Raloxifene hydrochloride treatment leads to better outcomes than medroxyprogesterone acetate when paired with estrogen in ovariectomized cholesterol-fed rabbits." Acta Biochim Biophys Sin (Shanghai) 46(12): 1080-1083.

Zhang, Y. and S. T. Davidge (1999). "Effect of estrogen replacement on vasoconstrictor responses in rat mesenteric arteries." Hypertension 34(5): 1117-1122.

Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold and J. M. Friedman (1994). "Positional cloning of the mouse obese gene and its human homologue." Nature 372(6505): 425-432.

Zoma, W. D., R. S. Baker and K. E. Clark (2000). "Coronary and uterine vascular responses to raloxifene in the sheep." Am J Obstet Gynecol 182(3): 521-528.

Zoth, N., C. Weigt, U. Laudenbach-Leschowski and P. Diel (2010). "Physical activity and estrogen treatment reduce visceral body fat and serum levels of leptin in an additive manner in a diet induced animal model of obesity." J Steroid Biochem Mol Biol 122(1-3): 100-105.